AISmall proteins designed by the model were evaluated in the laboratory.15Type of Target.14The design to combine in types was confirmed. According to the design conditions, the percentage of individual candidates combining is22.6and35.1It was % .
The AI design was combined in the 2 experiment.
Mini-binders are small proteins designed to bind strongly to target proteins, according to Anthropic, Claude Opus 4.8 and Mythos Preview are designed to combine the evaluable 15 types of targets, including 14 types.
Adaptyv Bio and Twist Bioscience actually manufactured the generated designs and evaluated the bonding in the laboratory. The processes for determining the interaction between the physically manufactured mini-protein and the target were incorporated, not solely by computational structural predictions.
Simultaneous treatment of all targets and comparison of targets.
When all targets were handled simultaneously in one session, Mythos Preview recorded a hit rate of 48% by 26.7% and Claude Opus 4.8 by 22.6% after running time.
Meanwhile, in multiple 24 time sessions where the Mythos Preview dealt with a single target, the overall hit rate reached 35.1% compared to the 10 to 15% that Anthropic represents as the standard for general protein design campaigns, with both simultaneous and targeted processing.
Measure the strength of your candidate.
In addition to whether or not there was a bond, the experiment also assessed the affinity to indicate how strongly the target was captured. At least the 6 type of target obtained a high affinity compound, and at least the 4 type confirmed a design that showed a greater affinity than the best value.
The design campaign was carried out to minimize human involvement after giving the necessary information at the first prompt. The method of handling all targets simultaneously was allocated a maximum of 100002500 NVIDIA H100 time, the target-specific method was allocated a maximum of 2500 NVIDIA H100 time, and a dedicated protein design model and folding model was used.
Connect the 1440 design to measurement values and process records
in the data set published,2which isAIThe model is16Designed for different types of targets.50and120Remains of de novo (new) miniature protein1440It has been recorded, and is mature.GDF-8to the direction.120The design made the experimental results uncertain by antigen coagulation and non-specific bonding to the measurement surface, and was excluded from the aggregation of the combined number.
For the remaining 15 type targets, 1320 designs combined 354 designs by integrating the assessments of 2. Each design includes combined assessments and speed data, unprocessed sensor graphs, structural predictions by multiple methods, and records of design processes.